Stromal fibroblasts in cancer initiation and progression
NA Bhowmick, EG Neilson, HL Moses - Nature, 2004 - nature.com
NA Bhowmick, EG Neilson, HL Moses
Nature, 2004•nature.comIt is widely accepted that the development of carcinoma—the most common form of human
cancer—is due to the accumulation of somatic mutations in epithelial cells. The behaviour of
carcinomas is also influenced by the tumour microenvironment, which includes extracellular
matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that
fibroblasts have a more profound influence on the development and progression of
carcinomas than was previously appreciated. These new findings have important …
cancer—is due to the accumulation of somatic mutations in epithelial cells. The behaviour of
carcinomas is also influenced by the tumour microenvironment, which includes extracellular
matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that
fibroblasts have a more profound influence on the development and progression of
carcinomas than was previously appreciated. These new findings have important …
Abstract
It is widely accepted that the development of carcinoma — the most common form of human cancer — is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.
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