[HTML][HTML] Vascular toxicities with VEGF inhibitor therapies–focus on hypertension and arterial thrombotic events
RM Touyz, SMS Herrmann, J Herrmann - Journal of the American Society of …, 2018 - Elsevier
The vascular endothelial growth factor (VEGF) signaling pathway (VSP) fulfills a cardinal
role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not
only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are
used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to
vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than
venous). All of these have been reported with VSP inhibitors and collectively give rise to …
role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not
only for the normal vasculature but also for the tumor vasculature when VSP inhibitors are
used as anti-angiogenic therapies. Generalized endothelial dysfunction predisposes to
vasoconstriction, atherosclerosis, platelet activation, and thrombosis (arterial more than
venous). All of these have been reported with VSP inhibitors and collectively give rise to …