First published May 1, 2015 - More info
The osteoblast-derived hormone osteocalcin promotes testosterone biosynthesis in the mouse testis by binding to GPRC6A in Leydig cells. Interestingly,
Franck Oury, Mathieu Ferron, Wang Huizhen, Cyrille Confavreux, Lin Xu, Julie Lacombe, Prashanth Srinivas, Alexandre Chamouni, Francesca Lugani, Herve Lejeune, T. Rajendra Kumar, Ingrid Plotton, Gerard Karsenty
Original citation: J Clin Invest. 2013;123(6):2421–2433. doi:10.1172/JCI65952.
Citation for this erratum: J Clin Invest. 2015;125(5):2180. doi:10.1172/JCI81812.
During the preparation of this manuscript, the genotype of the control animals was labeled incorrectly in Figure 5. The correct figure and legend are below.
Insulin signaling in osteoblasts favors testosterone production. (A) Testis size, and (B) testis, (C) epididymal, and (D) seminal vesicle weights normalized to BW (mg/g of BW); (E) sperm count; (F) circulating testosterone levels in InsRosb–/– versus InsRfl/fl (Cre–) male mice. (G) qPCR analysis of the expression of StAR, Cyp11a, Cyp17, 3β-HSD, Cyp19, and HSD-17 genes in testes of InsRosb–/– (n = 10) and InsRfl/fl (n = 12) mice. All analyses presented were performed on nonbreeder mix background (129/Sv: 87.5%; 129/Sv: 12.5%) mice. *P < 0.05; **P < 0.01.
The JCI regrets the error.