The series provides an overview over the JAK-STAT pathway and explores the important functions it plays in regulating immune responses and cellular homeostasis in human heath and disease.
Published May 2002
Most cancer patients die not from primary tumors but from metastatic disease. Besides the molecular basis for metastasis of human tumors, the series discusses the adhesive cellular interactions that are critical for invasive growth.
Published April 2002
Without extensive defense mechanisms, breathing would be dangerous. This series summarizes the current concepts underlying the biological processes that mediate the intrinsic and innate host defense against microbial invasion of the lung.
Published March 2002
Activation of immune cells must be tightly controlled. Articles in the series outline our current understanding of the delicate balance of positive and negative signals implicated in T cell activation, effector function, and apoptosis, and discuss the most pressing open questions.
Published January 2002
Inflammation and immunity are subject to neuroendocrine effects. The articles explore some of the developmental, physiological, and molecular interactions occurring at the immuno-neuroendocrine interface.
Published December 2001
The series outlines how autoantigen-specific responses arise and the mechanisms by which they specific pathologies. It also discusses how this understanding has changed and will affect management and prevention of autoimmune diseases.
Published October 2001
The series describes several examples of multiligand receptors. Some of these interact specifically with classes of structurally-related ligands, others bind structurally and functionally dissimilar molecules.
Published September 2001
Heparan sulfate proteoglycans are complex molecules consisting of a protein core and glycosaminoglycan side chains. Articles in the series summarize the current knowledge of heparan sulfate proteoglycan biology in various areas of basic biology and clinical medicine.
Published July 2001
The cyclooxygenases COX-1 and COX-2 catalyze the conversion of arachidonic acid to biologically active prostaglandins, which have numerous physiological functions. The series discusses the current status and future promise of prostaglandin research.
Published June 2001
This series on cell-matrix interactions discusses different molecules that mediate cell shape in vivo and in vitro, with a focus on the interpretation of extracellular signals at the cell surface.
Published April 2001